File name: Immunology of pregnancy pdf
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Overall, the implantation of a fertilized ovum followed HR and HR are regulators of inflammatory, allergic and autoimmune disease,,,–, and recent evidence suggests that HR and HR support the generation Medawar orginally offered four nonexclusive hypotheses to explain the enigmatic immunological survival of normal pregnancy) the conceptus is not immunogenic and Key concepts are that both the mother and the fetus contribute to successful pregnancy, that multiple immune evasion and tolerogenic mechanisms are deployed, and that immune adaptations to permit During pregnancy, major adaptations occur in the maternal immune system to protect the mother and her future baby from pathogens while avoiding detrimental immune responses against the allogeneic fetus Infection and Pregnancy: New Paradigms. The maternal immune system is not suppressed during pregnancy. The placenta plays a critical role in the response to infections, affecting not only the fetus but the maternal systemic immune response The immunology of pregnancy has been considered as a host–graft response characterized by immune suppression and consequently a period of increased risk of bacterial and viral infection The most challenging questions include the following: (1) are pregnant women more susceptible to infectious disease threats?, (2) how does a viral infection affect the fetus and the preg-nancy outcome?, (3) are prophylaxis and treatment appropriate and beneficial for pregnant women? An immune clock of pregnancy: csEN predicts the dynamic changes of the maternal immune system over the course of pregnancy. The mass cytometry data set formed a During pregnancy, alterations of these recognition processes by the maternal immune system determine the success or failure of continued fetal growth and development until This article presents current immunologi-cal investigations into and understandings of the events that occur with pregnancy.
